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Ephrin-Eph signaling in embryonic tissue separation.

Authors
  • Fagotto, Francois
  • Winklbauer, Rudolf
  • Rohani, Nazanin
Type
Published Article
Journal
Cell Adhesion & Migration
Publisher
Landes Bioscience
Publication Date
Jan 01, 2014
Volume
8
Issue
4
Pages
308–326
Identifiers
DOI: 10.4161/19336918.2014.970028
PMID: 25482630
Source
Medline
Keywords
License
Unknown

Abstract

The physical separation of the embryonic regions that give rise to the tissues and organs of multicellular organisms is a fundamental aspect of morphogenesis. Pioneer experiments by Holtfreter had shown that embryonic cells can sort based on "tissue affinities," which have long been considered to rely on differences in cell-cell adhesion. However, vertebrate embryonic tissues also express a variety of cell surface cues, in particular ephrins and Eph receptors, and there is now firm evidence that these molecules are systematically used to induce local repulsion at contacts between different cell types, efficiently preventing mixing of adjacent cell populations.

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