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Eosinophilic granulocytes as a possible source of vitamin B12-binding protein.

Authors
  • Mansouri, A
  • Perry, C A
  • Boyd, C M
  • Hsu, S D
Type
Published Article
Journal
Scandinavian journal of haematology
Publication Date
Nov 01, 1983
Volume
31
Issue
5
Pages
507–509
Identifiers
PMID: 6580720
Source
Medline
License
Unknown

Abstract

Leucocyte B12 and B12-binding capacity were measured by Simultrac radioassay in eosinophilic granulocytes, neutrophilic granulocytes and leucocytes obtained from patients with chronic granulocytic and lymphocytic leukaemia. It is shown that (a) eosinophils are a possible source of B12-binding protein similar to neutrophils and (b) granulocytes in myeloproliferative disorders and normal neutrophils have similar B12 and B12-binding capacity indicating that increased B12 and B12-binding capacity in myeloproliferative disorders arise from an increase in myeloid cell turnover.

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