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Eosinophilic esophagitis: novel concepts regarding pathogenesis and clinical manifestations.

Authors
  • Spechler, Stuart Jon1, 2
  • 1 Division of Gastroenterology and Center for Esophageal Diseases, Baylor University Medical Center, 3500 Gaston Avenue, 2 Hoblitzelle, Suite 250, Dallas, TX, 75246, USA. [email protected]
  • 2 Center for Esophageal Research, Baylor Scott & White Research Institute, Dallas, TX, USA. [email protected]
Type
Published Article
Journal
Journal of gastroenterology
Publication Date
Oct 01, 2019
Volume
54
Issue
10
Pages
837–844
Identifiers
DOI: 10.1007/s00535-019-01604-7
PMID: 31342146
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

This report explores two hypotheses regarding eosinophilic esophagitis (EoE): (1) that the use of proton pump inhibitors (PPIs) might contribute to the pathogenesis of EoE by preventing peptic digestion of food allergens, by increasing gastric mucosal permeability to enable gastric absorption of those undegraded food allergens, and by causing microbial dysbiosis, and (2) that EoE, like eosinophilic gastroenteritis, might have mucosal-predominant and muscle-predominant forms, and that the muscle-predominant form of EoE might cause a variety of esophageal motility disorders including achalasia.

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