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Eosinophilia-associated muscle disorders: an immunohistological study with tissue localisation of major basic protein in distinct clinicopathological forms.

Authors
  • Cantarini, L
  • Volpi, N
  • Carbotti, P
  • Greco, G
  • Aglianò, M
  • Bellisai, F
  • Giannini, F
  • Alessandrini, C
  • Grasso, G
  • Galeazzi, M
Type
Published Article
Journal
Journal of Clinical Pathology
Publisher
BMJ
Publication Date
May 01, 2009
Volume
62
Issue
5
Pages
442–447
Identifiers
DOI: 10.1136/jcp.2008.060616
PMID: 19139036
Source
Medline
License
Unknown

Abstract

MBP immunohistology on skeletal muscle, previously performed only for acute eosinophilic polymyositis, suggests that eosinophil-mediated injury of muscle cells may occur in a wider spectrum of less aggressive eosinophilia-associated myopathies than previously thought. As conventional histology is likely to underestimate this leucocyte subset, MBP staining may be a useful tool in the analysis of tissue infiltration of eosinophils as a possible treatment target.

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