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Eosinophilia-associated muscle disorders: an immunohistological study with tissue localisation of major basic protein in distinct clinicopathological forms.

Authors
Type
Published Article
Journal
Journal of Clinical Pathology
0021-9746
Publisher
BMJ
Publication Date
Volume
62
Issue
5
Pages
442–447
Identifiers
DOI: 10.1136/jcp.2008.060616
PMID: 19139036
Source
Medline

Abstract

MBP immunohistology on skeletal muscle, previously performed only for acute eosinophilic polymyositis, suggests that eosinophil-mediated injury of muscle cells may occur in a wider spectrum of less aggressive eosinophilia-associated myopathies than previously thought. As conventional histology is likely to underestimate this leucocyte subset, MBP staining may be a useful tool in the analysis of tissue infiltration of eosinophils as a possible treatment target.

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