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Enzymatic synthesis of dehydroderivatives from proline-containing cyclic dipeptides and their effects toward cell division.

Authors
  • Arunrattiyakorn, Panarat
  • Ikeda, Banri
  • Nitoda, Teruhiko
  • Kanzaki, Hiroshi
Type
Published Article
Journal
Bioscience, biotechnology, and biochemistry
Publication Date
Mar 01, 2007
Volume
71
Issue
3
Pages
830–833
Identifiers
PMID: 17341821
Source
Medline
License
Unknown

Abstract

We have previously isolated cyclo(L-Pro-L-Tyr) and cyclo(L-Phe-L-Pro) from an actinomycete by a novel enzymatic conversion-guided method. Their tetradehydro derivatives, cyclo(DeltaPro-DeltaTyr) and cyclo(DeltaPhe-DeltaPro), were enzymatically prepared. Neither of them inhibited cell division, in contrast to other tetradehydro cyclic dipeptides prepared previously. This result suggests that an NH proton in a diketopiperazine ring and/or conformation of the compound are important for the activity.

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