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[Enzymatic activity in the liver and lipogenesis processes in the fatty tissue of rats after a space flight].

Authors
  • Macho, L
  • Németh, S
  • Palkovics, M
  • Strbak, V
  • Tigranian, R A
Type
Published Article
Journal
Kosmicheskaia biologiia i aviakosmicheskaia meditsina
Publication Date
Jan 01, 1980
Volume
14
Issue
3
Pages
26–29
Identifiers
PMID: 7382401
Source
Medline
License
Unknown

Abstract

The rats flown aboard Cosmos-782 showed a significant increase in the activity of tyrosine aminotransferase and tryptophan pyrolase, i. e. the enzymes whose activity depends on the corticosterone level. The synchronous rats displayed a small increase in the enzyme activity. The flight and synchronous animals exhibited a slight increase in the activity of gluconeogenetic enzymes and a decrease in the activity of glucose-6-phosphatase. Immediately after flight and, to a lesser extent, after the synchronous experiment the activity of lipogenetic enzymes decreased. On the R+25 day the enzyme activity remained unchanged. The study of lipogenesis in the epididymal fat, using C14-glucose incorporation into lipids, did not reveal any differences in the flight and synchronous rats. The findings demonstrated that changes in the enzyme activity induced by the flight and synchronous experiments returned to the normal during readaptation.

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