Although the primary end point of a 20% PFS rate was not achieved, 13% of the patients had PFS for >or= 6 months. Given the tolerability and survival data, evaluation of enzastaurin in combination with cytotoxic drugs is warranted in NSCLC.
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The corresponding record at NLM can be accessed at https://www.ncbi.nlm.nih.gov/pubmed/18309949