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Envisioning the innovations in nanomedicine to combat visceral leishmaniasis: for future theranostic application

Authors
  • Singh, Om Prakash1
  • Gedda, Mallikarjuna Rao1
  • Mudavath, Shyam Lal1, 2
  • Srivastava, Onkar Nath3
  • Sundar, Shyam1
  • 1 Infectious Disease Research Laboratory, Department of Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India
  • 2 Department of Chemical Biology & Therapeutics, Institute of Nano Science & Technology, Habitat Centre, Phase 10, Sector 64, Mohali, Punjab, India
  • 3 Department of Physics, Institute of Science, Banaras Hindu University, Varanasi, India
Type
Published Article
Journal
Nanomedicine
Publisher
Future Medicine
Publication Date
Jul 03, 2019
Volume
14
Issue
14
Pages
1911–1927
Identifiers
DOI: 10.2217/nnm-2018-0448
PMID: 31313971
PMCID: PMC7006826
Source
PubMed Central
Keywords
License
Unknown

Abstract

Visceral leishmaniasis (VL) is a life-threatening parasitic disease affecting impoverished people of the developing world; and much effort has been spent on the early case detection and treatment. However, current diagnostics and treatment options are not sufficient for appropriate surveillance in VL elimination setting. Hence, there is a dire need to develop highly sensitive diagnostics and less toxic effective treatments for proper management of cases and to achieve the sustained disease elimination. Although, promising results have been observed with nanomedicines in leishmaniasis; there are great challenges ahead especially in translating this to clinical setting. This review provides updated progress of nanomedicines in VL, and discussed how these innovations and future directions play vital role in achieving VL elimination.

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