Affordable Access

Environmental and dietary risk factors in Alzheimer's disease.

Authors
  • Dosunmu, Remi
  • Wu, Jinfang
  • Basha, Md Riyaz
  • Zawia, Nasser H
Type
Published Article
Journal
Expert Review of Neurotherapeutics
Publisher
Informa UK (Taylor & Francis)
Publication Date
Jul 01, 2007
Volume
7
Issue
7
Pages
887–900
Identifiers
PMID: 17610395
Source
Medline
License
Unknown

Abstract

Alzheimer's disease (AD) is a progressive neurodegenerative disease that affects millions in the aging population worldwide and will affect millions more in the next 20 years. Over 90% of all cases are sporadic, with genetics playing a minor role in the etiology of AD. Therefore, it is crucial to investigate the environment and diet as primary risk factors in AD pathology. This review considers epidemiologic case control studies, and in vitro and in vivo research to investigate the potential of environmental exposure to metals, air pollution and pesticides as well as diet as risk factors for AD. In some cases, the role of genetic mutations and environmental risk is discussed. The evidence examined in this review provides a brief overview of the current literature on selected, significant risk factors in promoting amyloid-beta accumulation and aggregation, thus contributing to neurodegeneration.

Report this publication

Statistics

Seen <100 times