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Entrapment of Radionuclides in Nanoparticle Compositions

  • Andresen, Thomas Lars
  • Petersen, Anncatrine Luisa
  • Henriksen, Jonas Rosager
  • Rasmussen, Palle
  • kjær, Andreas
Publication Date
Jan 01, 2012
Online Research Database In Technology
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The present invention is directed to the technical field of imaging compositions useful for diagnosing cancer and other diseases in a subject. In particular, the invention relates to a class of diagnostic compounds comprising a novel liposome composition with encapsulated metal entities such as radionuclides,for example 61Cu and 64Cu copper isotopes. The invention further relates to a novel method for loading delivery systems, such as liposome compositions, with metal entities such as radionuclides, and the use of liposomes for targeted diagnosis and treatment of a target site, such as cancerous tissue and, in general, pathological conditions associated with leaky blood vessels. The present invention provides a new diagnostic tool for the utilization of positron emission tomography (PET) imaging technique.

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