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Entorhinal fibers form synaptic contacts on parvalbumin-immunoreactive neurons in the rat fascia dentata.

Authors
  • Zipp, F
  • Nitsch, R
  • Soriano, E
  • Frotscher, M
Type
Published Article
Journal
Brain Research
Publisher
Elsevier
Publication Date
Aug 21, 1989
Volume
495
Issue
1
Pages
161–166
Identifiers
PMID: 2776034
Source
Medline
License
Unknown

Abstract

The entorhinal cortex gives rise to a dense projection to the outer two-thirds of the dentate molecular layer. The main target neurons are the granule cells. This study demonstrates that entorhinal fibers labeled by anterograde degeneration also terminate on parvalbumin-containing non-granule cells in the rat fascia dentata. Since the calcium-binding protein parvalbumin was recently found coexistent with gamma-aminobutyric acid in inhibitory hippocampal neurons, the described connection provides evidence for a role of entorhinal fibers in feed-forward inhibition of the granule cells.

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