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[Entecavir--close perspective for using it].

Authors
  • Halota, Waldemar
  • Pawłowska, Małgorzata
Type
Published Article
Journal
Przegla̧d epidemiologiczny
Publication Date
Jan 01, 2006
Volume
60
Issue
1
Pages
115–118
Identifiers
PMID: 16758749
Source
Medline
License
Unknown

Abstract

There are 3 drugs registered to treatment of chronic hepatitis B: interferon, lamivudine and adefovir. Many other nucleoside and nucleotide analougs are examined. In experiments on the animals: woodchucks infected with WHBV and ducks infected with DHBV beneficial influence of entecavir on viral DNA and cccDNA supression. In these examination no resistance was present. In clinical studies resistanse to entecavir conserned only patients with resistance to lamivudine. Entecavir is safety and effective in the treatment of chronic hepatits B in patients HBeAg positive and negative and in patients with resistance to lamivudine.

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