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Ensemble-Level Organization of Human Kinetochores and Evidence for Distinct Tension and Attachment Sensors

Authors
  • Roscioli, Emanuele1, 2
  • Germanova, Tsvetelina E.1, 2
  • Smith, Christopher A.1, 2
  • Embacher, Peter A.1, 3
  • Erent, Muriel1, 2
  • Thompson, Amelia I.1, 2
  • Burroughs, Nigel J.1, 3
  • McAinsh, Andrew D.1, 2
  • 1 Centre for Mechanochemical Cell Biology, University of Warwick, Coventry, UK
  • 2 Division of Biomedical Sciences, Warwick Medical School, University of Warwick, Coventry, UK
  • 3 Mathematics Institute, University of Warwick, Coventry, UK
Type
Published Article
Journal
Cell Reports
Publisher
Elsevier
Publication Date
Apr 28, 2020
Volume
31
Issue
4
Identifiers
DOI: 10.1016/j.celrep.2020.107535
PMID: 32348762
PMCID: PMC7196887
Source
PubMed Central
Keywords
License
Unknown

Abstract

Roscioli et al. use subpixel imaging and computational methods to determine the ensemble-level 3D organization of the human kinetochore. They show how kinetochores undergo distinct rearrangements in response to the loss of attachment and tension.

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