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Enriched enteral nutrition may improve short-term survival in stage IV gastric cancer patients: A randomized, controlled trial.

  • Klek, Stanislaw1
  • Scislo, Lucyna2
  • Walewska, Elzbieta2
  • Choruz, Ryszard3
  • Galas, Aleksander4
  • 1 Stanley Dudrick's Memorial Hospital, General Surgery Unit, Skawina, Poland. Electronic address: [email protected] , (Poland)
  • 2 Department of Clinical Nursing, Institute of Nursing and Midwifery, Faculty of Health Care, Jagiellonian University, Krakow, Poland. , (Poland)
  • 3 Stanley Dudrick's Memorial Hospital, General Surgery Unit, Skawina, Poland. , (Poland)
  • 4 Department of Epidemiology, Jagiellonian University Medical College, Krakow, Poland. , (Poland)
Published Article
Nutrition (Burbank, Los Angeles County, Calif.)
Publication Date
Apr 01, 2017
DOI: 10.1016/j.nut.2016.03.016
PMID: 28336107


The aim of the study was to determine whether the postoperative use of enteral nutrition enriched with arginine, glutamine, and omega-3 fatty acids influences survival in patients diagnosed with stomach cancer. For the purpose of the study, the second wave of the trial performed in 2003 to 2009 was done. Ninety-nine patients who underwent surgery for gastric cancer (27 F, 72 M, mean age: 62.9 y) met the inclusion criteria. Of those, 54 were randomized to standard and 45 to enriched enteral nutrition (EEN). In all patients, short- and long-term (5 y) survival was analyzed. Analysis of the overall survival time did not reveal differences between groups (P = 0.663). Until the end of the third month, however, there were nine deaths in the standard enteral nutrition group and no deaths in the EEN group (16.7% versus 0.0%, P = 0.004). The univariate analyses suggested that the EEN group may have lower risk, especially during the first year after intervention. A significant reduction in the risk of death was seen during the early period after surgery (first 6 mo) in the EEN group in stage IV patients (hazard ratio = 0.25, P = 0.049). The use of enriched enteral diet did not influence, however, the risk of dying when patients were analyzed together. The study does not support the beneficial effect of enriched enteral nutrition in long-term survival; however, the positive impact on the stage IV patients suggests the need for further, more detailed studies. Copyright © 2016 Elsevier Inc. All rights reserved.

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