Affordable Access

Enlargement of the membranous ventricular septum: an internal stigma of Down's syndrome.

Authors
  • Rosenquist, G C
  • Sweeney, L J
  • Amsel, J
  • McAllister, H A
Type
Published Article
Journal
The Journal of Pediatrics
Publisher
Elsevier
Publication Date
Oct 01, 1974
Volume
85
Issue
4
Pages
490–493
Identifiers
PMID: 4280438
Source
Medline
License
Unknown

Abstract

A study of heart specimens without ventricular septal defect from patients with down's syndrome showed a significant enlargement of the membranous ventricular septum as compared to the normal heart. This increase in area of the ventricular septum occupied by membranous tissue from 2 to 9% may not only predispose patients with Down's syndrome to congenital heart disease, but may be one end of a spectrum of cardiac anomalies related to malalignment or maldevelopment of the ventricular septum in Down's syndrome.

Report this publication

Statistics

Seen <100 times