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Enigmatic Cassandra: renal FGF23 formation in polycystic kidney disease.

Authors
  • Lang, Florian
  • Föller, Michael
Type
Published Article
Journal
Kidney International
Publisher
Elsevier
Publication Date
Jun 01, 2014
Volume
85
Issue
6
Pages
1260–1262
Identifiers
DOI: 10.1038/ki.2013.534
PMID: 24875546
Source
Medline
License
Unknown

Abstract

Fibroblast growth factor 23 (FGF23) counteracts phosphate excess and tissue calcification. Phosphate intake, Ca(2+), parathyroid hormone, and 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) stimulate FGF23 release from bone. FGF23 inhibits renal 1,25(OH)2D3 formation and phosphate reabsorption. Spichtig and colleagues demonstrate that FGF23 is generated in rodent polycystic kidneys, leading to an increase in plasma FGF23 concentration before reduction in kidney function. FGF23 fails to appreciably downregulate renal phosphate transporter and 1α-25OH-vitamin D hydroxylase activities. Unraveling underlying mechanisms may open diagnostic and therapeutic opportunities.

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