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Enhancement of methyldopa metabolism with barbiturate.

Authors
  • Káldor, A
  • Juvancz, P
  • Demeczky, M
  • Sebestyen, K
  • Palotas, J
Type
Published Article
Journal
BMJ
Publisher
BMJ
Publication Date
Aug 26, 1971
Volume
3
Issue
5773
Pages
518–519
Identifiers
PMID: 5570647
Source
Medline
License
Unknown

Abstract

The spurious increase in serum catecholamine levels associated with methyldopa treatment can be reduced by the simultaneous administration of phenobarbitone. This accelerating effect of phenobarbitone on methyldopa metabolism has been demonstrated in relation to both adrenaline and noradrenaline, and investigations suggest that it is due to the effect of barbiturate on the activity of metabolizing enzymes.

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