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Enhancement of enzymatic fibrinolysis with 2-MHz ultrasound and microbubbles.

Authors
  • Cintas, P
  • Nguyen, F
  • Boneu, B
  • Larrue, V
Type
Published Article
Journal
Journal of thrombosis and haemostasis : JTH
Publication Date
Jul 01, 2004
Volume
2
Issue
7
Pages
1163–1166
Identifiers
PMID: 15219200
Source
Medline
License
Unknown

Abstract

The application of galactose-based microbubbles (Levovist) strongly accelerates lysis of clots exposed to 2 MHz, low-intensity US in vitro both with and without rt-PA. The findings suggest a synergy between microbubbles and rt-PA. These methods routinely used for transcranial diagnostic applications have the potential to improve the efficacy of intravenous rt-PA in acute ischemic stroke.

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