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Enhancement of alcohol withdrawal convulsions in mice by haloperidol.

Authors
  • Blum, K
  • Eubanks, J D
  • Wallace, J E
  • Hamilton, H
Type
Published Article
Journal
Clinical toxicology
Publication Date
Jan 01, 1976
Volume
9
Issue
3
Pages
427–434
Identifiers
PMID: 986285
Source
Medline
License
Unknown

Abstract

Based on the data presented here and the clinical observations cited it would appear that although haloperidol has been used with a certain degree of success for the treatment of acute alcohol abstinence the authors would like to caution the clinician against widespread use of heloperidol for treatment of alcohol withdrawal. In experimentally induced ethanol withdrawal, chlordiazepoxide appears to be a more effective and safer agent for ameliorating symptoms associated with excitation such as tremor, insomnia, anxiety, and hyperexcitability. A double blind comparative clinical investigation between chlordiazepoxide and haloperidol for treatment of alcohol withdrawal is warranted.

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