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Enhanced vasodilatory responses to bradykinin in stroke-prone spontaneously hypertensive rats.

Authors
  • Stier, C T Jr
  • Selig, N
  • Itskovitz, H D
Type
Published Article
Journal
European Journal of Pharmacology
Publisher
Elsevier
Publication Date
Jan 14, 1992
Volume
210
Issue
2
Pages
217–219
Identifiers
PMID: 1601060
Source
Medline
License
Unknown

Abstract

Vasodilatory responses to bradykinin (BK) and acetylcholine (ACh) were compared in phenylephrine preconstricted perfused kidneys from 30-week-old male stroke-prone spontaneously hypertensive rats (SHRSP) and normotensive Wistar-Kyoto rats (WKY). Responses to ACh did not differ between kidneys from SHRSP and WHY. BK-induced dilatation was greater in kidneys from SHRSP relative to WHY and was not affected by indomethacin or captopril. These results indicate that renal vasodilatory responsiveness to bradykinin is enhanced in SHRSP with established hypertension.

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