Affordable Access

deepdyve-link deepdyve-link
Publisher Website

Enhanced skeletal muscle expression of extracellular superoxide dismutase mitigates streptozotocin-induced diabetic cardiomyopathy by reducing oxidative stress and aberrant cell signaling.

Authors
  • Call, Jarrod A
  • Chain, Kristopher H
  • Martin, Kyle S
  • Lira, Vitor A
  • Okutsu, Mitsuharu
  • Zhang, Mei
  • Yan, Zhen
Type
Published Article
Journal
Circulation Heart Failure
Publisher
Ovid Technologies Wolters Kluwer -American Heart Association
Publication Date
Jan 01, 2015
Volume
8
Issue
1
Pages
188–197
Identifiers
DOI: 10.1161/CIRCHEARTFAILURE.114.001540
PMID: 25504759
Source
Medline
Keywords
License
Unknown

Abstract

Enhanced expression of EcSOD in skeletal muscle is sufficient to mitigate streptozotocin-induced diabetic cardiomyopathy through attenuation of oxidative stress, aberrant cell signaling, and inflammation, suggesting a cross-organ mechanism by which exercise training improves cardiac function in diabetes mellitus.

Report this publication

Statistics

Seen <100 times