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Enhanced skeletal muscle expression of extracellular superoxide dismutase mitigates streptozotocin-induced diabetic cardiomyopathy by reducing oxidative stress and aberrant cell signaling.

Authors
Type
Published Article
Journal
Circulation Heart Failure
1941-3297
Publisher
Ovid Technologies Wolters Kluwer -American Heart Association
Publication Date
Volume
8
Issue
1
Pages
188–197
Identifiers
DOI: 10.1161/CIRCHEARTFAILURE.114.001540
PMID: 25504759
Source
Medline
Keywords
License
Unknown

Abstract

Enhanced expression of EcSOD in skeletal muscle is sufficient to mitigate streptozotocin-induced diabetic cardiomyopathy through attenuation of oxidative stress, aberrant cell signaling, and inflammation, suggesting a cross-organ mechanism by which exercise training improves cardiac function in diabetes mellitus.

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