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Enhanced peripheral T-cell apoptosis in chronic hepatitis C virus infection: association with liver disease severity.

Authors
  • Toubi, E
  • Kessel, A
  • Goldstein, L
  • Slobodin, G
  • Sabo, E
  • Shmuel, Z
  • Zuckerman, E
Type
Published Article
Journal
Journal of Hepatology
Publisher
Elsevier
Publication Date
Dec 01, 2001
Volume
35
Issue
6
Pages
774–780
Identifiers
PMID: 11738105
Source
Medline
License
Unknown

Abstract

We confirm previous reports that enhanced T-cell apoptosis in HCV infection may play an important role in disease severity. Decreased expression of NFkappaB is important in the development of peripheral T-cell apoptosis, thus contributing to viral persistence and autoimmunity in these patients.

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