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Enhanced liver fibrosis (ELF) score: Reference ranges, biological variation in healthy subjects, and analytical considerations.

Authors
  • Jabor, Antonín1
  • Kubíček, Zdenek2
  • Fraňková, Soňa3
  • Šenkeříková, Renáta4
  • Franeková, Janka5
  • 1 Institute for Clinical and Experimental Medicine, Department of Laboratory Methods, Vídeňská 1958/9, Praha 4, Czech Republic. Electronic address: [email protected] , (Czechia)
  • 2 Institute for Clinical and Experimental Medicine, Department of Laboratory Methods, Vídeňská 1958/9, Praha 4, Czech Republic. , (Czechia)
  • 3 Institute for Clinical and Experimental Medicine, Hepatogastroenterology Department, Vídeňská 1958/9, Praha 4, Czech Republic. Electronic address: [email protected] , (Czechia)
  • 4 Institute for Clinical and Experimental Medicine, Hepatogastroenterology Department, Vídeňská 1958/9, Praha 4, Czech Republic. Electronic address: [email protected] , (Czechia)
  • 5 Institute for Clinical and Experimental Medicine, Department of Laboratory Methods, Vídeňská 1958/9, Praha 4, Czech Republic. Electronic address: [email protected] , (Czechia)
Type
Published Article
Journal
Clinica chimica acta; international journal of clinical chemistry
Publication Date
Aug 01, 2018
Volume
483
Pages
291–295
Identifiers
DOI: 10.1016/j.cca.2018.05.027
PMID: 29772213
Source
Medline
Keywords
License
Unknown

Abstract

The reference range of the ELF score overlap with the area defined as moderate fibrosis by the manufacturer. High biological variation of HA was diminished by the natural logarithm in the calculation of the ELF score. The use of the ELF score has suitable analytical and acceptable biological performance characteristics for clinical practice. However, the transfer of results evaluated in healthy persons to the populations with chronic liver diseases deserves caution.

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