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Enhanced cerebro-cerebellar functional connectivity reverses cognitive impairment following electroconvulsive therapy in major depressive disorder.

Authors
  • Wei, Qiang1, 2
  • Ji, Yang1
  • Bai, Tongjian1, 2
  • Zu, Meidan1
  • Guo, Yuanyuan1
  • Mo, Yuting1
  • Ji, Gongjun2
  • Wang, Kai3, 4, 5, 6
  • Tian, Yanghua7, 8
  • 1 Department of Neurology, the First Affiliated Hospital of Anhui Medical University, 230022, Hefei, Anhui Province, China. , (China)
  • 2 Collaborative Innovation Centre of Neuropsychiatric Disorders and Mental Health, Hefei, China. , (China)
  • 3 Department of Neurology, the First Affiliated Hospital of Anhui Medical University, 230022, Hefei, Anhui Province, China. [email protected] , (China)
  • 4 Collaborative Innovation Centre of Neuropsychiatric Disorders and Mental Health, Hefei, China. [email protected] , (China)
  • 5 Anhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders, 230022, Hefei, China. [email protected] , (China)
  • 6 Department of Medical Psychology, Anhui Medical University, 230022, Hefei, China. [email protected] , (China)
  • 7 Department of Neurology, the First Affiliated Hospital of Anhui Medical University, 230022, Hefei, Anhui Province, China. [email protected] , (China)
  • 8 Collaborative Innovation Centre of Neuropsychiatric Disorders and Mental Health, Hefei, China. [email protected] , (China)
Type
Published Article
Journal
Brain Imaging and Behavior
Publisher
Springer-Verlag
Publication Date
Apr 01, 2021
Volume
15
Issue
2
Pages
798–806
Identifiers
DOI: 10.1007/s11682-020-00290-x
PMID: 32361944
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Electroconvulsive therapy (ECT), a rapidly acting and effective treatment for major depressive disorder (MDD), is frequently accompanied by cognitive impairment. Recent studies have documented that ECT reorganizes dysregulated inter/intra- connected cerebral networks, including the affective network, the cognitive control network(CCN) and default mode network (DMN).Moreover, cerebellum is thought to play an important role in emotion regulation and cognitive processing. However, little is known about the relationship between cerebro-cerebellar connectivity alterations following ECT and antidepressant effects or cognitive impairment. We performed seed-based resting-state functional connectivity (RSFC) analyses in 28 MDD patients receiving ECT and 20 healthy controls to identify cerebro-cerebellar connectivity differences related to MDD and changes induced by ECT. Six seed regions (three per hemisphere) in the cerebrum were selected for RSFC, corresponding to the affective network, CCN and DMN, to establish cerebro-cerebellar functional connectivity with cerebellum. MDD patients showed increased RSFC between left sgACC and left cerebellar lobule VI after ECT. Ggranger causality analyses (GCA) identified the causal interaction is from left cerebellar lobule VI to left sgACC. Furthermore, increased effective connectivity from left cerebellar lobule VI to left sgACC exhibited positively correlated with the change in verbal fluency test (VFT) score following ECT (r = 0.433, p = 0.039). Our findings indicate that the enhanced cerebro-cerebellar functional connectivity from left lobule VI to left sgACC may ameliorate cognitive impairment induced by ECT. This study identifies a potential neural pathway for mitigation of cognitive impairment following ECT.

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