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Engineering preferences of hairpin PNA binding to complementary DNA: effect of N7G in aeg/aep PNA backbone.

Authors
  • Kumar, V A
  • D'Costa, M
  • Ganesh, K N
Type
Published Article
Journal
Nucleosides, nucleotides & nucleic acids
Publication Date
Jan 01, 2001
Volume
20
Issue
4-7
Pages
1187–1191
Identifiers
PMID: 11562983
Source
Medline
License
Unknown

Abstract

AegPNA and aepPNA monomeric units bearing the N7-guanine nucleobase as a substitute for C+ have been demonstrated to bind to a GC base-pair of a duplex in a pH-independent manner when placed in the third strand. The aepPNA backbone exerts a preference for binding in the antiparallel Hoogsteen mode over the parallel Hoogsteen mode.

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