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Engineering microenvironment of biodegradable polyester systems for drug stability and release control.

Authors
  • Khaliq, Nisar Ul1
  • Chobisa, Dhawal1, 2
  • Richard, Coralie A3
  • Swinney, Monica R4
  • Yeo, Yoon1, 5
  • 1 Department of Industrial & Physical Pharmacy, Purdue University, 575 Stadium Mall Drive, West Lafayette, IN 47907, USA.
  • 2 Integrated Product Development Organization, Innovation Plaza, Dr.Reddy's Laboratories, Hyderabad 500090, India. , (India)
  • 3 Eli Lilly & Company,893 Delaware Street, Indianapolis, IN 46225, USA. , (India)
  • 4 Eli Lilly & Company, 450 Kendall Street, Cambridge, MA 02142, USA.
  • 5 Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN 47907, USA.
Type
Published Article
Journal
Therapeutic Delivery
Publisher
"Future Science, LTD"
Publication Date
Jan 05, 2021
Identifiers
DOI: 10.4155/tde-2020-0113
PMID: 33397135
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Polymeric systems made of poly(lactic acid) or poly(lactic-co-glycolic acid) are widely used for long-term delivery of small and large molecules. The advantages of poly(lactic acid)/poly(lactic-co-glycolic acid) systems include biodegradability, safety and a long history of use in US FDA-approved products. However, as drugs delivered by the polymeric systems and their applications become more diverse, the significance of microenvironment change of degrading systems on long-term drug stability and release kinetics has gained renewed attention. In this review, we discuss various issues experienced with acidifying microenvironment of biodegradable polymer systems and approaches to overcome the detrimental effects of polymer degradation on drug stability and release control.

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