Affordable Access

Access to the full text

Engineered T cells Flt around their targets

Authors
  • Morris, Emma C.1
  • 1 University College London, London, UK , London (United Kingdom)
Type
Published Article
Journal
Nature Immunology
Publisher
Springer Nature
Publication Date
Jul 09, 2020
Volume
21
Issue
8
Pages
831–832
Identifiers
DOI: 10.1038/s41590-020-0740-3
Source
Springer Nature
License
Yellow

Abstract

Antigen escape by solid tumors has limited the efficacy of genetically modified T cells. T cells engineered to secrete the cytokine Flt3L induce the activation of endogenous T cells, enabling a broader repertoire of tumor antigens to be targeted via the expansion of intratumoral antigen presenting cells, significantly improving tumor responses.

Report this publication

Statistics

Seen <100 times