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Engagement of integrins as a cellular route of invasion by bacterial pathogens.

Authors
  • Scibelli, Antonio
  • Roperto, Sante
  • Manna, Laura
  • Pavone, Luigi Michele
  • Tafuri, Simona
  • Della Morte, Rossella
  • Staiano, Norma
Type
Published Article
Journal
The Veterinary Journal
Publisher
Elsevier
Publication Date
May 01, 2007
Volume
173
Issue
3
Pages
482–491
Identifiers
PMID: 16546423
Source
Medline
License
Unknown

Abstract

Integrins are heterodimeric receptors that mediate important cell functions, including cell adhesion, migration and tissue organisation. These transmembrane receptors regulate the direct association of cells with each other and with extracellular matrix proteins. However, by binding their ligands, integrins provide a transmembrane link for the bidirectional transmission of mechanical forces and biochemical signals across the plasma membrane. Interestingly, several of this family of receptors are exploited by pathogens to establish contact with the host cells. Hence, microbes subvert normal eukaryotic cell processes to create a specialised niche which allows their survival. This review highlights the fundamental role of integrins in bacterial pathogenesis.

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