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Energy Requirements for Loss of Viral Infectivity

Authors
  • Rowell, Caroline E. R.1, 2
  • Dobrovolny, Hana M.2
  • 1 Wingate University,
  • 2 Texas Christian University,
Type
Published Article
Journal
Food and Environmental Virology
Publisher
Springer US
Publication Date
Aug 05, 2020
Pages
1–14
Identifiers
DOI: 10.1007/s12560-020-09439-9
PMID: 32757142
PMCID: PMC7405386
Source
PubMed Central
Keywords
License
Unknown

Abstract

Outside the host, viruses will eventually lose their ability to infect cells due to conformational changes that occur to proteins on the viral capsid. In order to undergo a conformational change, these proteins require energy to activate the chemical reaction that leads to the conformational change. In this study, data from the literature is used to calculate the energy required for viral inactivation for a variety of different viruses by means of the Arrhenius equation. We find that some viruses (rhinovirus, poliovirus, human immunodeficiency virus, Alkhumra hemorrhagic fever virus, and hepatitis A virus) have high inactivation energies, indicative of breaking of a chemical double bond. We also find that several viruses (respiratory syncytial virus, poliovirus, and norovirus) have nonlinear Arrhenius plots, suggesting that there is more than a single pathway for inactivation of these viruses. Electronic supplementary material The online version of this article (10.1007/s12560-020-09439-9) contains supplementary material, which is available to authorized users.

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