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Energy metabolism in demented brain.

Authors
Type
Published Article
Journal
Progress in Neuro-Psychopharmacology and Biological Psychiatry
0278-5846
Publisher
Elsevier
Publication Date
Volume
10
Issue
3-5
Pages
591–597
Identifiers
PMID: 3541053
Source
Medline
License
Unknown

Abstract

The term dementia refers to a number of very complicated disorders of the brain with several morphological, biochemical and functional alterations. Several alterations occur in Alzheimer's disease. They include alteration in neurotransmitters related substances and changes in brain metabolic rate. Changes in metabolic activity are among the earliest and best documented of all modification reported in Alzheimer's brain. They appear to be correlate with the severity of the disease, and to be more marked in specific areas of the brain which appear to be clinically more involved. In this report will be discussed the observations on changes of cerebral glucose metabolic rate, cerebral oxygen consumption, cerebral blood flow reported in vivo in demented patients. The observations of changes in energy metabolism related enzymes and the relationship between these changes and those in neurotransmitters related substances will be also reviewed.

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