This paper presents a theoretical comparison among different commercial refrigeration systems in terms of annual energy consumption and environmental impact. Eight configurations were studied: a R744/R134a cascade refrigeration system (baseline), a conventional and an improved R744 booster system, two R744 booster solutions with dedicated mechanical subcooling, a R744 booster with parallel compression and two solutions which combined the parallel compression and the mechanical subcooling. The evaluation was based on the weather data in Valencia (Spain) and in Athens (Greece), as well as on the running modes of a conventional European supermarket. A transition zone, which occurred between sub critical and transcritical operations, was adopted.The results showed that all the enhanced configurations may achieve a comparable energy saving to the one of the baseline in both the selected locations. Furthermore, they allow reducing the Total Equivalent Warming Impact (TEWI) by at least 9.6% beside the cascade solution. (C) 2016 Elsevier Ltd and IIR. All rights reserved.