The energetics of cellular life transitions.
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Authors
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Monzel, Anna S1
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Levin, Michael2, 3, 4
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Picard, Martin1, 5, 6, 7
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1
Department of Psychiatry, Division of Behavioral Medicine, College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY 10032, United States.
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(United States)
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2
Department of Biology, Tufts University, Medford, MA 02155, United States.
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(United States)
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3
Allen Discovery Center at Tufts University, Medford, MA 02155, United States.
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(United States)
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4
Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, United States.
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(United States)
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5
Department of Neurology, H. Houston Merritt Center, Columbia Translational Neuroscience Initiative, College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY 10032, United States.
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(United States)
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6
New York State Psychiatric Institute, New York, NY 10032, United States.
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(United States)
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7
Robert N Butler Columbia Aging Center, Columbia University Mailman School of Public Health, New York, NY 10032, United States.
,
(United States)
- Type
- Published Article
- Journal
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Life metabolism
- Publication Date
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Jun 01, 2024
- Volume
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3
- Issue
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3
- Identifiers
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DOI: 10.1093/lifemeta/load051
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PMID: 38566850
- Source
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Medline
- Keywords
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- Language
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English
- License
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Unknown
Abstract
Major life transitions are always difficult because change costs energy. Recent findings have demonstrated how mitochondrial oxidative phosphorylation (OxPhos) defects increase the energetic cost of living, and that excessive integrated stress response (ISR) signaling may prevent cellular identity transitions during development. In this perspective, we discuss general bioenergetic principles of life transitions and the costly molecular processes involved in reprograming the cellular hardware/software as cells shift identity. The energetic cost of cellular differentiation has not been directly quantified, representing a gap in knowledge. We propose that the ISR is an energetic checkpoint evolved to i) prevent OxPhos-deficient cells from engaging in excessively costly transitions, and ii) allow ISR-positive cells to recruit systemic energetic resources by signaling via the brain.
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
This record was last updated on 04/13/2024 and may not reflect the most current and accurate biomedical/scientific data available from NLM.
The corresponding record at NLM can be accessed at
https://www.ncbi.nlm.nih.gov/pubmed/38566850
