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The energetic cost of NNT-dependent ROS removal

Authors
  • Kaludercic, Nina1
  • Di Lisa, Fabio1, 2
  • 1 Neuroscience Institute, National Research Council of Italy (CNR), Padova, Italy
  • 2 Department of Biomedical Sciences, University of Padova, Padova, Italy
Type
Published Article
Journal
Journal of Biological Chemistry
Publisher
American Society for Biochemistry and Molecular Biology
Publication Date
Nov 27, 2020
Volume
295
Issue
48
Pages
16217–16218
Identifiers
DOI: 10.1074/jbc.H120.016368
PMID: 33246940
PMCID: PMC7705306
Source
PubMed Central
License
Unknown

Abstract

Under conditions of high nutrient availability and low ATP synthesis, mitochondria generate reactive oxygen species (ROS) that must be removed to avoid cell injury. Among the enzymes involved in this scavenging process, peroxidases play a crucial role, using NADPH provided mostly by nicotinamide nucleotide transhydrogenase (NNT). However, scarce information is available on how and to what extent ROS formation is linked to mitochondrial oxygen consumption. A new study by Smith et al. shows that NNT activity maintains low ROS levels by means of a fine modulation of mitochondrial oxygen utilization.

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