Affordable Access

deepdyve-link
Publisher Website

END-phenomenon negative bovine viral diarrhea virus that induces the host's innate immune response supports propagation of BVDVs with different immunological properties.

Authors
  • Shiokawa, Mai1
  • Omatsu, Tsutomu2
  • Katayama, Yukie2
  • Nishine, Kaoru3
  • Fujimoto, Yuri4
  • Uchiyama, Shiori1
  • Kameyama, Ken-Ichiro5
  • Nagai, Makoto2
  • Mizutani, Tetsuya2
  • Sakoda, Yoshihiro4
  • Fukusho, Akio1
  • Aoki, Hiroshi6
  • 1 School of Veterinary Nursing and Technology, Faculty of Veterinary Science, Nippon Veterinary and Life Science University, Tokyo, Japan. , (Japan)
  • 2 Research and Education Center for Prevention of Global Infectious Disease of Animal, Faculty of Agriculture, Tokyo University of Agriculture and Technology, Tokyo, Japan. , (Japan)
  • 3 School of Veterinary Nursing and Technology, Faculty of Veterinary Science, Nippon Veterinary and Life Science University, Tokyo, Japan; Kyoto Biken Laboratories, Inc. Formulation Department, Formulation Section 1, Kyoto, Japan. , (Japan)
  • 4 Laboratory of Microbiology, Department of Disease Control, Faculty of Veterinary Medicine, Hokkaido University, Hokkaido, Japan. , (Japan)
  • 5 Division of Transboundary Animal Disease, National Institute of Animal Health, NARO, Ibaraki, Japan. , (Japan)
  • 6 School of Veterinary Nursing and Technology, Faculty of Veterinary Science, Nippon Veterinary and Life Science University, Tokyo, Japan. Electronic address: [email protected] , (Japan)
Type
Published Article
Journal
Virology
Publisher
Elsevier
Publication Date
Dec 01, 2019
Volume
538
Pages
97–110
Identifiers
DOI: 10.1016/j.virol.2019.09.016
PMID: 31590058
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Our previous study reported that persistently infected (PI) cattle of bovine viral diarrhea virus (BVDV) have co-infected with BVDV/END- and /END+ that promote and inhibit host's type-I interferon (IFN) production, respectively. However, the relationship between co-infection of immunologically distinct BVDVs and persistent infection as well as the biological significance of END- viruses remains unknown. Experiments using cultured cells revealed that END+ virus, which is unable to propagate in situations where the host's immune response is induced by IFN-α addition, is able to propagate under those conditions when co-infecting with END- virus. These results indicate that BVDV/END- can coexist with BVDV/END+ and that co-infection with END- viruses supports the propagation of END+ viruses. Our in vitro experiments strongly suggest that co-infection with END- virus is involved in the maintenance of persistent infection of BVDV. Copyright © 2019 Elsevier Inc. All rights reserved.

Report this publication

Statistics

Seen <100 times