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The endothelium-dependent relaxation of human middle cerebral artery: effects of activated neutrophils.

Authors
  • Akopov, S E
  • Grigorian, M R
  • Gabrielian, E S
Type
Published Article
Journal
Experientia
Publication Date
Jan 15, 1992
Volume
48
Issue
1
Pages
34–36
Identifiers
PMID: 1737573
Source
Medline
License
Unknown

Abstract

Neutrophils, activated by 4 beta-phorbol-12 beta-myristate-13 alpha-acetate, decreased acetylcholine-induced relaxation of strips of human middle cerebral artery precontracted with noradrenaline. This effect was prevented by catalase, but not by superoxide dismutase. Nifedipine, propranolol and, less markedly, captopril reduced the decrease in acetylcholine-induced relaxation. Aspirin and dipyridamole did not reduce it.

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