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Endothelin-1 may act as a negative inotropic agent in cardiac myocytes from young and senescent rats.

Authors
  • Fraticelli, A
  • Rossi, L
  • Socillo, A I
  • Boria, C
  • Capogrossi, M C
  • Paciaroni, E
Type
Published Article
Journal
Archives of Gerontology and Geriatrics
Publisher
Elsevier
Publication Date
Jan 01, 1992
Volume
15 Suppl 1
Pages
151–158
Identifiers
PMID: 18647685
Source
Medline
License
Unknown

Abstract

The contractile response to Endothelin-1 (ET-1) has been investigated in electrically stimulated single cardiac myocytes isolated from hearts of young and senescent rats. ET-1 (0.1-10 nM) exhibited a marked negative inotropic effect in both age groups. ET-1 (1.0 nM) also reduced the occurrence of spontaneous contractile oscillations in young myocytes, suggesting depletion of sarcoplasmic reticulum-Ca(2+) stores. The possibility that ET-1 may have opposite effects on myocardial contractility is discussed.

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