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Endothelial thrombomodulin (CD 141) in a rabbit burn model.

Authors
  • von Bülow, Silvester
  • Hartmann, Th
  • Fuchs, P C
  • Schrimpf, C
  • Pallua, N
Type
Published Article
Journal
Burns
Publisher
Elsevier
Publication Date
Jun 01, 2005
Volume
31
Issue
4
Pages
459–464
Identifiers
PMID: 15896508
Source
Medline
License
Unknown

Abstract

Thermal injuries affect the dermal endothelial surfaces resulting in a shedding of thrombomodulin. This mechanism might be involved in the development of progressive skin damage in the zone of stasis. Disseminated intravascular coagulation following inactivation of thrombomodulin might lead to multiple organ dysfunctions in severe burn injuries.

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