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[Endothelial relaxation factor as a local modulator of arterial function. The possibility of stabilization].

Authors
  • Vedernikov, Iu P
  • Gräzer, T
  • Osis, Iu G
Type
Published Article
Journal
Fiziologicheskiĭ zhurnal SSSR imeni I. M. Sechenova
Publication Date
Feb 01, 1988
Volume
74
Issue
2
Pages
153–161
Identifiers
PMID: 3259514
Source
Medline
License
Unknown

Abstract

Endothelium-derived relaxing factor (EDRF) exerted no inhibitory effect on papillary muscles or the rat portal vein. Externally applied acetylcholine did not reach aorta endothelium to stimulate the EDRF release in rabbits, nor bradykinin in the pig coronary artery segments. Acetylcholine penetrated, however, canine femoral artery wall and stimulated the release of EDRF. Stabilizing of the EDRF released from perfused rabbit thoracic aorta, seems to be possible.

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