Affordable Access

Access to the full text

Endothelial Dysfunction in SARS-CoV-2 Infection

Authors
  • nappi;, francesco
Publication Date
Mar 11, 2022
Identifiers
DOI: 10.3390/biomedicines10030654
OAI: oai:mdpi.com:/2227-9059/10/3/654/
Source
MDPI
Keywords
Language
English
License
Green
External links

Abstract

One of the hallmarks of the SARS-CoV-2 infection has been the inflammatory process that played a role in its pathogenesis, resulting in mortality within susceptible individuals. This uncontrolled inflammatory process leads to severe systemic symptoms via multiple pathways; however, the role of endothelial dysfunction and thrombosis have not been truly explored. This review aims to highlight the pathogenic mechanisms of these inflammatory triggers leading to thrombogenic complications. There are direct and indirect pathogenic pathways of the infection that are examined in detail. We also describe the case of carotid artery thrombosis in a patient following SARS-CoV-2 infection while reviewing the literature on the role of ACE2, the endothelium, and the different mechanisms by which SARS-CoV-2 may manifest both acutely and chronically. We also highlight differences from the other coronaviruses that have made this infection a pandemic with similarities to the influenza virus.

Report this publication

Statistics

Seen <100 times