Affordable Access

deepdyve-link
Publisher Website

Endoscopy and cross-sectional imaging for assessing Crohn׳s disease activity.

Authors
  • Stidham, Ryan W1
  • Cross, Raymond K1
  • 1 Division of Gastroenterology and Hepatology, Department of Internal Medicine, University of Michigan Health System, Ann Arbor, MI, USA.
Type
Published Article
Journal
Techniques in gastrointestinal endoscopy
Publication Date
Jul 01, 2016
Volume
18
Issue
3
Pages
123–130
Identifiers
DOI: 10.1016/j.tgie.2016.08.001
PMID: 28458507
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Crohn's disease (CD) is principally characterized by chronic and recurrent inflammation of the gastrointestinal tract, most commonly found in the ileo-colonic region. The chronicity and severity of intestinal inflammation together contribute to progressive, cumulative, deep, transmural intestinal damage, including stricturing, obstruction, abscesses, and fistulae. Both intestinal inflammation and its chronic complications result in a range of symptoms subsequently leading to patient presentations with diarrhea, abdominal pain, and anemia related to intestinal blood loss. Measuring disease activity and severity are essential for decision of treatment intensity early in the disease course and longitudinal monitoring of therapeutic efficacy. This review will summarize the transition from subjective symptoms driving disease activity indices, into increasingly objective and quantitative measures of intestinal injury by direct mucosal assessment (endoscopy), cross-sectional imaging, and surrogate biomarkers. Specific commentary on intestinal stricture and perianal fistula assessment and management are presented in accompanying sections of this series.

Report this publication

Statistics

Seen <100 times