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Endoprotease profiling with double-tagged peptide substrates: a new diagnostic approach in oncology.

Authors
  • Peccerella, Teresa
  • Lukan, Nadine
  • Hofheinz, Ralf
  • Schadendorf, Dirk
  • Kostrezewa, Markus
  • Neumaier, Michael
  • Findeisen, Peter
Type
Published Article
Journal
Clinical Chemistry
Publisher
American Association for Clinical Chemistry
Publication Date
Feb 01, 2010
Volume
56
Issue
2
Pages
272–280
Identifiers
DOI: 10.1373/clinchem.2009.133462
PMID: 20110451
Source
Medline
License
Unknown

Abstract

The introduction of a few structural key elements (affinity tags, linkers, d-amino acids) into synthetic reporter peptides increases the diagnostic sensitivity for MS-based protease profiling of serum specimens. This new approach might lead to functional MS-based protease profiling for improved disease classification.

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