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Endometrioid adenocarcinoma presenting in a patient 18 years after hysterectomy: a potential hazard of unopposed oestrogen therapy.

Authors
  • Ronga, Alvaro Bedoya1
  • Najia, Salim K
  • Sahasrabudhe, Neil
  • Prescott, Richard
  • Buruiana, Felicia Elena
  • Heazell, Alexander
  • 1 Stoke Mandeville Hospital, Obstetrics and Gynaecology, Flat C, 17-19 Guildford Street, Luton LU1 2NQ, UK.
Type
Published Article
Journal
BMJ Case Reports
Publisher
BMJ
Publication Date
Jan 01, 2009
Volume
2009
Identifiers
DOI: 10.1136/bcr.05.2009.1829
PMID: 21841948
Source
Medline
License
Unknown

Abstract

We present a case of endometrioid adenocarcinoma arising from extragonadal endometriosis 18 years after total abdominal hysterectomy with bilateral salpingo-oophorectomy. After the primary surgery the patient received 11 years of unopposed oestrogen hormone replacement therapy. She presented with symptoms of urinary retention and pelvic mass. Following resection, histopathology identified the mass as an endometrioid adenocarcinoma. The association between persistent endometriosis and the development of endometrial cancer are discussed here together with the risks of unopposed oestrogen in the development of such lesions.

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