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Endomembrane remodeling in autophagic membrane formation.

Authors
  • Zhang, Min1
  • Wang, Yu1
  • Ge, Liang1
  • 1 a The State Key Laboratory of Membrane Biology , Tsinghua University-Peking University Joint Center for Life Sciences , School of Life Sciences , Tsinghua University , Beijing , China. , (China)
Type
Published Article
Journal
Autophagy
Publisher
Landes Bioscience
Publication Date
Apr 03, 2018
Pages
1–3
Identifiers
DOI: 10.1080/15548627.2018.1425053
PMID: 29368983
Source
Medline
Keywords
License
Unknown

Abstract

Autophagosomal membrane sources generate autophagic membrane precursors, which later assemble into the double-membrane autophagosome. The key events happening on the membrane sources during autophagic membrane generation remain poorly characterized. Our previous work found the ER-Golgi intermediate compartment (ERGIC) as a membrane source for the phagophore, the precursor to the autophagosome. A relocation of the COPII machinery from the ER-exit sites (ERES) to the ERGIC generates vesicles for LC3 lipidation. In recent work, we made a further step by showing that a starvation-induced remodeling of ERES facilitates the relocation of COPII to the ERGIC and the generation of the autophagic membrane.

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