The authors present the case of a female patient who, following complicated surgery, developed endogenous endophthalmitis. Based on the clinical picture and microscopic finding in the punctuate of the affected vitreous body the diagnosis of endogenous mycotic endophthalmitis was established. The treatment of the condition is based on a combination of local and systemic administration of antimycotics. If medicamentous treatment is not effective, pars plana vitrectomy must be performed. In severe cases surgical treatment is selected as soon as the diagnosis is confirmed.