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Endogenous inhibitors of human choline acetyltransferase present in Alzheimer's brain: preliminary observation.

Authors
  • Singh, I
  • Xu, C
  • Pettegrew, J W
  • Kanfer, J N
Type
Published Article
Journal
Neurobiology of Aging
Publisher
Elsevier
Publication Date
Jan 01, 1994
Volume
15
Issue
5
Pages
643–649
Identifiers
PMID: 7824057
Source
Medline
License
Unknown

Abstract

We have previously demonstrated the presence in Alzheimer's disease brain of an endogenous inhibitor of choline acetyltransferase activity. Selected properties of these compounds were investigated. There appear to be two distinct classes of inhibitor present, both phosphomonoesters and nonphosphorylated substances. They are not proteins, pass through 500 mm dialyses membranes and are not lipoidal. There are both different sensitivities of individual control cytosotic activity to inhibition and differences in intrinsic inhibitory activity present in individual Alzheimer's disease brain samples. There is a competitive type of inhibition with respect to acetyl CoA as substrate and a noncompetitive type with respect to choline as substrate.

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