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Endogenous electric currents might guide rostral migration of neuroblasts.

Authors
Type
Published Article
Journal
EMBO Reports
Publisher
EMBO
Volume
14
Issue
2
Pages
184–184
Identifiers
DOI: 10.1038/embor.2012.215
Source
zhaolab-ucdavis dermatology-ucdavis
License
Unknown

Abstract

Mechanisms that guide directional migration of neuroblasts from the subventricular zone (SVZ) are not well understood. We report here that endogenous electric currents serve as a guidance cue for neuroblast migration. We identify the existence of naturally occurring electric currents (1.5±0.6 μA/cm(2), average field strength of ∼3 mV/mm) along the rostral migration path in adult mouse brain. Electric fields of similar strength direct migration of neuroblasts from the SVZ in culture and in brain slices. The purinergic receptor P2Y1 mediates this migration. The results indicate that naturally occurring electric currents serve as a new guidance mechanism for rostral neuronal migration.

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