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Endocrine disrupting-chemicals and biochemical recurrence of prostate cancer after prostatectomy: A cohort study in Guadeloupe (French West Indies).

Authors
  • Brureau, Laurent1
  • Emeville, Elise2
  • Helissey, Carole3
  • Thome, Jean Pierre4
  • Multigner, Luc2
  • Blanchet, Pascal1
  • 1 CHU de Pointe-à-Pitre, Univ Antilles, Univ Rennes, Inserm, EHESP, Irset (Institut de recherche en santé, environnement et travail) - UMR_S 1085, Pointe-à-Pitre, France. , (France)
  • 2 Univ Rennes, Inserm, EHESP, Irset (Institut de recherche en santé, environnement et travail) - UMR_S 1085, Rennes, France. , (France)
  • 3 Département d'Oncologie Médicale, Unité de Recherche Clinique, Hôpital d'Instruction Militaire Begin, Saint Mandé, France. , (France)
  • 4 LEAE-CART (Laboratoire d'Ecologie Animale et d'Ecotoxicologie-Centre de Recherche Analytique et Technologique), Université de Liège, Liège, Belgium. , (Belgium)
Type
Published Article
Journal
International Journal of Cancer
Publisher
Wiley (John Wiley & Sons)
Publication Date
Feb 01, 2020
Volume
146
Issue
3
Pages
657–663
Identifiers
DOI: 10.1002/ijc.32287
PMID: 30892691
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Previous studies have suggested that exposure to environmental chemicals with hormonal properties, also called endocrine disrupting chemicals, may be involved in the occurrence of prostate cancer (PCa). Such exposure may also influence the treatment outcome as it is still present at the time of diagnosis, the beginning of therapy, and beyond. We followed 326 men in Guadeloupe (French West Indies) who underwent radical prostatectomy as primary treatment of localized PCa. We analyzed the relationship between exposure to the estrogenic chlordecone, the antiandrogenic dichlorodiphenyldichloroethylene (DDE, the main metabolite of the insecticide DDT), and the nondioxin-like polychlorinated biphenyl congener 153 (PCB-153) with mixed estrogenic/antiestrogenic properties and the risk of biochemical recurrence (BCR) after surgery. After a median follow-up of 6.1 years after surgery, we found a significant increase in the risk of BCR, with increasing plasma chlordecone concentration (adjusted hazard ratio = 2.51; 95% confidence interval: 1.39-4.56 for the highest vs. lowest quartile of exposure; p trend = 0.002). We found no associations for DDE or PCB-135. These results shown that exposure to environmental estrogens may negatively influence the outcome of PCa treatment. © 2019 UICC.

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