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Endocannabinoids modulate Gq/11 protein-coupled receptor agonist-induced vasoconstriction via a negative feedback mechanism.

Authors
  • Karpińska, Olga1
  • Baranowska-Kuczko, Marta1
  • Kloza, Monika1
  • Kozłowska, Hanna1
  • 1 Department of Experimental Physiology and Pathophysiology, Medical University of Białystok, Białystok, Poland. , (Poland)
Type
Published Article
Journal
The Journal of pharmacy and pharmacology
Publication Date
Nov 17, 2017
Identifiers
DOI: 10.1111/jphp.12854
PMID: 29148061
Source
Medline
Keywords
License
Unknown

Abstract

Endocannabinoid's negative feedback is responsible for diminishing agonist-induced vasoconstriction, which may be clinically important in the treatment of arterial and pulmonary hypertension. Further research is required to establish the importance of the eCB system and its downstream signalling pathways.

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