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Enantioselective rhodium-catalyzed arylation of cyclic N-sulfamidate alkylketimines: a new access to chiral β-alkyl-β-aryl amino alcohols.

Authors
  • Chen, Ya-Jing
  • Chen, Ya-Heng
  • Feng, Chen-Guo
  • Lin, Guo-Qiang
Type
Published Article
Journal
Organic Letters
Publisher
American Chemical Society
Publication Date
Jun 20, 2014
Volume
16
Issue
12
Pages
3400–3403
Identifiers
DOI: 10.1021/ol501464e
PMID: 24922499
Source
Medline
License
Unknown

Abstract

The enantioselective rhodium-catalyzed 1,2-addition of arylboronates to cyclic N-sulfamidate alkylketimines was developed. With a rhodium/diene complex as catalyst, high enantioselectivity and broad functional group tolerance were observed. The resulting sulfamidates can easily be converted into chiral β-alkyl-β-aryl amino alcohols.

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