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Enantioselective organocatalytic Michael addition of aldehydes to trifluoroethylidene malonates.

Authors
  • Wen, Lele
  • Shen, Qilong
  • Lu, Long
Type
Published Article
Journal
Organic Letters
Publisher
American Chemical Society
Publication Date
Oct 15, 2010
Volume
12
Issue
20
Pages
4655–4657
Identifiers
DOI: 10.1021/ol101894h
PMID: 20849077
Source
Medline
License
Unknown

Abstract

An efficient, highly enantioselective, organocatalytic Michael addition reaction of aldehydes with trifluoroethylidene malonates is described. The asymmetric reaction provided highly optically pure β-trifluoromethyl aldehydes which can be conveniently transformed into 4,4,4-trifluoromethyl butyric acid and trifluoromethyl substituted δ-lactones without loss in enantioselectivity.

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